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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Leaflet length and left main coronary artery occlusion following transcatheter aortic valve replacement
Kazuaki Okuyama1, Hasan Jilaihawi, Raj R Makkar
1Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Insights
Coronary artery occlusion is a rare but severe complication of transcatheter aortic valve replacement. A novel predictor, the leaflet-to-coronary sinus ratio (L/C), may help identify patients at risk.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Coronary artery occlusion is a rare, severe complication during transcatheter aortic valve replacement (TAVR).
- Definitive etiologies and predictors remain largely unknown due to limited case numbers.
- This complication can be life-threatening, necessitating prompt intervention.
Observation:
- A case of left main coronary artery occlusion occurred immediately after prosthetic valve deployment during TAVR.
- The patient experienced hemodynamic compromise, including hypotension and cardiopulmonary arrest.
- Successful coronary artery stenting under cardiopulmonary bypass led to patient recovery.
Findings:
- Pre-procedural computed tomography (CT) did not reveal conventional predictors like low coronary height.
- Retrospective review indicated a long prosthetic valve leaflet potentially covering the left main coronary artery ostium.
- A novel potential predictor, the ratio of leaflet length to curved coronary sinus height (L/C), was identified.
Implications:
- The L/C ratio may serve as a new predictive tool for coronary artery occlusion post-TAVR.
- Understanding leaflet-valve interactions is crucial for preventing this severe complication.
- Further research is warranted to validate the L/C ratio in larger patient cohorts.
Abstract:
Coronary artery occlusion during transcatheter aortic valve replacement is a rare complication. However, it is a very severe and life-threatening event. Although there are some possible causes of this phenomenon, definite etiologies and predictors are unknown because of the small number. We describe one case of left main coronary artery occlusion immediately after deployment of a prosthetic valve. The patient became hypotensive and developed cardiopulmonary arrest. However, the coronary artery was successfully stented with a help of cardiopulmonary bypass and he recovered well. In this case, pre-procedural computed tomography (CT) showed the adequately high coronary height and no other significant conventional predictor for coronary occlusion. The examinations were retrospectively reviewed and the CT showed a long leaflet compared to the coronary sinus complex. The fluoroscopy appeared to show the long leaflet covering the left main coronary artery ostium immediately after the valve deployment. The height of the coronary artery ostium from the aortic annulus appeared sufficiently high in this case and did not explain the coronary compromise; leaflet length in relation to the coronary sinus dimension seemed more relevant. The ratio between leaflet length and curved coronary sinus height (L/C) may be one novel predictor for coronary artery occlusion.
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