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Updated: May 10, 2026

Gas Chromatography-Mass Spectrometry-Based Targeted Metabolomics of Hard Coral Samples
Published on: October 13, 2023
Bioactive terpenoids from the Red Sea soft coral Sinularia polydactyla
El-Sayed A Aboutabl1, Shadia M Azzam, Camilia G Michel
1a Department of Pharmacognosy , Cairo University , Giza , Egypt.
Abstract:
Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3β,25-diol (2), in addition to a cembranoid diterpene, durumolide C (3), for the first time. The cytotoxicity and antimicrobial activities of the ethyl acetate extract and the isolated compounds 1-3 were evaluated in vitro. Durumolide C (3) showed selective cytotoxicity against HepG2 (IC50 1.0 μg/mL), whereas 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1) showed IC50 of 6.1 and 8.2 μg/mL against Hep2 and HCT human cancer cell lines, respectively.
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