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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
B-lymphocyte signalling abnormalities and lupus immunopathology.
Taher E Taher1, Hawzheen A Muhammad, Edwige Bariller
1Bone & Joint Research Unit, William Harvey Research Institute, Barts.
International Reviews of Immunology
|June 18, 2013
Summary
Intracellular signaling defects in B-lymphocytes contribute to lupus pathogenesis. These abnormalities affect B-lymphocyte tolerance, cytokine production, and infection responses in both mouse models and human patients.
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Background:
- Lupus is a complex autoimmune disease with unknown causes.
- B-lymphocytes are central to lupus immunological abnormalities, but atypical responses are not fully understood.
- Intracellular signaling pathways regulate B-lymphocyte function.
Purpose of the Study:
- To review current knowledge on intracellular signaling abnormalities in B-lymphocytes in lupus.
- To explore the effects of these defects on B-lymphocyte responses in lupus models and patients.
- To provide molecular and genetic explanations for lupus-associated immunological abnormalities.
Main Methods:
- Review of existing literature on intracellular signaling in lupus B-lymphocytes.
- Analysis of data from lupus mouse models and genetically engineered mice.
- Examination of B-lymphocytes from lupus patients.
- Inclusion of genome-wide linkage analyses.
Main Results:
- Numerous defects in the regulation of intracellular signaling proteins and pathways in lupus B-lymphocytes have been identified.
- Evidence from mouse models increasingly aligns with findings from human patient studies.
- Signaling defects impact B-lymphocyte tolerance, cytokine production, and responses to infections.
Conclusions:
- Intracellular signaling abnormalities in B-lymphocytes offer molecular and genetic insights into lupus pathogenesis.
- These defects are crucial for understanding key immunological dysfunctions in lupus.
- Further research into these signaling pathways may reveal therapeutic targets for lupus.
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