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Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Temperature controlled machine perfusion system for liver.

H Obara¹, N Matsuno, T Shigeta

¹Department of Mechanical Engineering, Tokyo Metroplitan University, Tokyo, Japan. obara@tmu.ac.jp

Transplantation Proceedings

|June 18, 2013

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A new machine perfusion (MP) system, NES-01, effectively preserves liver grafts. This innovative method evaluates graft viability, offering a promising alternative to static cold storage for improved organ transplantation outcomes.

Area of Science:

Transplantation immunology
Organ preservation technologies
Surgical innovation

Background:

Static cold storage limits organ viability and transplant success.
Machine perfusion (MP) offers superior organ preservation compared to static cold storage.
Developing advanced MP systems is crucial for utilizing extended criteria and donation after cardiac death (DCD) organs.

Purpose of the Study:

To introduce and evaluate a novel machine perfusion preservation system (NES-01).
To assess the efficacy of NES-01 in preserving porcine liver grafts.
To determine the utility of NES-01 in evaluating graft viability for functional recovery.

Main Methods:

Development of a new machine perfusion system (NES-01) capable of controlling perfusate temperature from hypothermic to subnormothermic conditions.

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Application of the NES-01 system for the preservation of porcine liver grafts.

Evaluation of graft viability and potential for functional recovery using the NES-01 system.

Main Results:

The NES-01 system successfully preserved porcine liver grafts.
The system demonstrated potential for evaluating graft viability for recovery.
Controlled hypothermic to subnormothermic perfusion was achieved.

Conclusions:

The novel NES-01 machine perfusion system is effective for liver graft preservation.
This system aids in assessing graft viability, crucial for improving organ transplant success.
The technology holds promise for organs from challenging donor sources, including DCD donors.