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Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Cytomegalovirus Disease01:27

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Updated: May 10, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.

Dirk P Dittmer1, Blossom Damania

  • 1Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, Program in Global Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.

Current Opinion in Virology
|June 18, 2013
PubMed
Summary

Kaposi sarcoma-associated herpesvirus (KSHV) drives cancer by promoting infected cell survival and proliferation. This review covers recent advances in understanding KSHV

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

Published on: August 15, 2025

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • Kaposi sarcoma-associated herpesvirus (KSHV) is a human oncogenic virus.
  • KSHV causes various human cancers.
  • Viral proteins manipulate host cell pathways.

Purpose of the Study:

  • To review recent advancements in KSHV pathogenesis.
  • To highlight KSHV's role in modulating cellular pathways.
  • To discuss KSHV's impact on innate immunity.

Main Methods:

  • Literature review of KSHV pathogenesis.
  • Analysis of viral protein functions.
  • Examination of host-pathogen interactions.

Main Results:

  • KSHV proteins promote cell proliferation and inhibit apoptosis.
  • KSHV modulates innate immune responses for cell survival.
  • Viral strategies ensure infected cell persistence during latency.

Conclusions:

  • KSHV employs multiple proteins to control host cell fate.
  • Understanding KSHV pathogenesis is crucial for cancer treatment.
  • Recent research deepens insights into KSHV-induced malignancies.