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Updated: May 10, 2026

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Published on: April 3, 2015

Animal models for vascular tissue-engineering.

Daniel D Swartz¹, Stelios T Andreadis

¹Department of Pediatrics, University at Buffalo, The State University of New York, Amherst, NY 14260-4200, United States; Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, United States.

Current Opinion in Biotechnology

|June 18, 2013

Summary

This summary is machine-generated.

Tissue-engineered vascular grafts (TEVs) are crucial for cardiovascular disease treatment. This review highlights animal models used to test TEVs, ensuring their safety and efficacy before human clinical application.

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Last Updated: May 10, 2026

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Cardiovascular Research

Background:

Rising global cardiovascular disease necessitates effective vascular graft alternatives.
Small-diameter blood vessel grafts are in high demand for replacement therapies.
Autologous vessels are not always suitable for patients requiring grafts.

Purpose of the Study:

To review and analyze animal models for testing small-diameter tissue-engineered vascular grafts (TEVs).
To emphasize the specific attributes and applications of various animal models.
To assess the suitability of these models for preclinical evaluation of vascular grafts.

Main Methods:

Review of literature on animal models used in TEV research.
Categorization of models into small animal (short-term patency, mechanistic studies) and large preclinical animal models (long-term patency, remodeling, function).
Discussion of recent clinical trials involving laboratory-fabricated TEVs.

Main Results:

Small animal models are effective for initial patency testing and hypothesis-driven research.
Large preclinical models provide a human-physiology-mimicking environment for comprehensive graft evaluation.
Recent clinical trials of TEVs demonstrate promising outcomes.

Conclusions:

Animal models are essential for optimizing vascular graft performance before clinical implantation.
A tiered approach using small and large animal models ensures robust preclinical assessment.
Successful clinical trials validate the potential of TEVs in treating cardiovascular disease.