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Updated: May 10, 2026

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography
Published on: August 25, 2023
Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1
Alejandro de Athayde Moncorvo Collado1, Natalia Corbalán, László Homolya
1Instituto Superior de Investigaciones Biológicas (CONICET-UNT), Instituto de Química Biológica Dr. Bernabe Bloj, San Miguel de Tucumán, Argentina.
Abstract:
ABCG1 is a half-sized transporter with an unquestionable importance in cholesterol homeostasis. So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPAR agonists including polyphenols. However, it is unknown whether there are other mechanisms of up-regulation of ABCG1 activity. In the present work resveratrol was shown to induce a nearly twofold increase in ATPase activity of reconstituted ABCG1. Evidence is presented for the first time suggesting that resveratrol is able to activate ABCG1 activity by an alternative mechanism that involves an indirect interaction.
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