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Plasma tissue factor pathway inhibitor levels in angiographically defined coronary artery disease among saudis
1Associate Professor, Department of Physiology (29), College of Medicine, PO Box 2925, King Saud University, Riyadh 11461, Kingdom of Saudi Arabia.
Insights
Plasma levels of total tissue factor pathway inhibitor (TFPI-T) are elevated in Saudi patients with coronary artery disease (CAD). Higher TFPI-T levels correlate with increased CAD severity, suggesting its potential as a diagnostic marker.
Area of Science:
- Cardiovascular Medicine
- Hemostasis and Thrombosis
- Biomarkers in Disease
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- Understanding the hemostatic factors involved in CAD pathogenesis is crucial for diagnosis and prognosis.
- Tissue factor pathway inhibitor (TFPI) plays a role in regulating coagulation.
Purpose of the Study:
- To measure plasma levels of total (TFPI-T) and free (TFPI-F) tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (t-PA) in Saudi CAD patients.
- To assess the correlation between these hemostatic markers and the severity of CAD.
- To evaluate the potential of TFPI-T as a diagnostic and prognostic marker in CAD.
Main Methods:
- Cross-sectional study involving 60 Saudi patients with angiographically defined CAD and 39 healthy controls.
- Analysis of plasma levels of TFPI-T, TFPI-F, PAI-1, and t-PA.
- Assessment of CAD severity using Gensini and vessel scores.
Main Results:
- CAD patients exhibited significantly higher levels of Fibrinogen, PAI-1, TFPI-T, and TFPI-F compared to controls.
- Plasma t-PA levels did not differ between groups.
- TFPI-T showed a significant positive correlation with both Gensini scores (r=0.344, p=0.006) and vessel scores (r=0.338, p=0.015).
Conclusions:
- Plasma TFPI-T levels are significantly associated with the presence and severity of coronary artery disease.
- Elevated TFPI-T may serve as a valuable diagnostic and prognostic biomarker for patients with CAD.
Objectives:
This study was aimed to determine plasma levels of total (TFPI-T) and free (TFPI-F) tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (t-PA) in a cohort of Saudi patients with chronic stable angiographically defined coronary artery disease (CAD) and to determine its correlation with its severity.
Methods:
This cross sectional study was conducted in the department of physiology and department of cardiology, College of Medicine, and King Khalid University Hospital and King Saud University, Riyadh. Sixty known cases of CAD who had undergone angiography (35 males and 25 females) were selected. A control group included 39 (20 males and 19 females) healthy subjects. Fasting venous blood samples were analyzed for total (TFPI-T) and free (TFPI-F) tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (t-PA). Gensini scores and vessel scores were determined for assessing CAD severity.
Results:
There were non-significant differences between age, body mass index (BMI) and Blood pressure between the controls and CAD subjects. A comparison of hemostatic markers between control and CAD patients showed significantly higher levels of Fibrinogen, PAI-1, TFPI-T and TFPI-F in CAD patients compared to control subjects. But there was no difference in plasma t-PA levels. TFPI-T had a significant positive correlation with severity of disease determined by Gensini Scores (r=0.344; p=0.006) and vessel scores (r=0.338; p=0.015).
Conclusion:
Plasma levels of total tissue factor pathway inhibitor are significantly related with the presence and severity of CAD. Elevated levels of TFPI-T may be considered as useful diagnostic and prognostic markers in patients with CAD.
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