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A case of crimean-congo hemorrhagic Fever in oman
Matllooba Al-Zadjali1, Hakeem Al-Hashim, Mohammad Al-Ghilani
1Oman Medical Board, Muscat, Sultanate of Oman.
Oman Medical Journal
|June 18, 2013
Insights
Crimean-Congo hemorrhagic fever (CCHF) reappeared in Oman in 2011. Early PCR tests were negative, but later serology confirmed CCHF, and the patient successfully responded to ribavirin treatment.
Area of Science:
- * Infectious Diseases
- * Viral Hemorrhagic Fevers
- * Medical Diagnostics
Background:
- * Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with significant mortality.
- * Oman has not reported CCHF cases for over 15 years prior to this event.
- * Timely and accurate diagnosis is crucial for effective patient management.
Observation:
- * A patient in Oman presented with symptoms suggestive of a viral illness in June 2011.
- * Initial diagnostic tests, including reverse transcriptase polymerase chain reaction (PCR), for CCHF and other arboviruses were negative.
- * A subsequent serological test performed five days later yielded a strong positive result for CCHF.
Findings:
- * The patient was diagnosed with Crimean-Congo hemorrhagic fever based on positive serology.
- * Treatment with the antiviral drug ribavirin was initiated promptly.
- * The patient demonstrated a dramatic clinical improvement following ribavirin therapy.
Implications:
- * This case highlights the potential re-emergence of CCHF in regions where it was previously dormant.
- * The study underscores the importance of repeated diagnostic testing and serological confirmation in suspected CCHF cases.
- * Effective management with ribavirin suggests its continued utility in treating CCHF patients.
Abstract:
In the summer of June 2011, the first case of Crimean-Congo hemorrhagic fever (CCHF) was observed in Oman since the last fifteen years. The first blood sample using reverse transcriptase polymerase chain reaction (PCR) test were sent looking for CCHF, tick-borne encephalitis, dengue, Japanese encephalitis, Chikungunya and West Nile. All resulted as negative. The repeated serology for CCHF came strongly positive after five days from the initial negative test, and accordingly patient started on ribavirin and he responded to it. His condition improved dramatically.
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