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Updated: May 10, 2026
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart
Published on: January 7, 2019
Clinical application of adult stem cells for therapy for cardiac disease
Ali Ghodsizad1, Arjang Ruhparwar, Viktor Bordel
1Heart and Vascular Institute, Milton S. Hershey Medical Center, College of Medicine, The Pennsylvania State University, Hershey, PA, USA; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Insights
Cell-based therapies offer a promising new avenue for treating cardiovascular disease, particularly for patients unresponsive to traditional treatments. Ongoing research explores various stem cell types and their potential in regenerative medicine for heart failure.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Cell-based Therapies
Background:
- Cardiovascular disease remains a leading global cause of mortality.
- Standard treatments are ineffective for a significant patient subset.
- Cell-based therapies present emerging therapeutic strategies.
Purpose of the Study:
- To provide a comprehensive review of current clinical data on cell therapy for cardiovascular disease.
- To highlight the potential of cell-based approaches in regenerative medicine.
Main Methods:
- Review of existing clinical trial data on cell therapy for cardiovascular conditions.
- Analysis of various stem cell types utilized in clinical applications.
Main Results:
- Initial clinical trials with cell-based therapies have yielded promising outcomes.
- Diverse adult stem cell populations, including mesenchymal stem cells and CD34(+) cells, have been employed.
- These therapies are being investigated for end-stage heart failure.
Conclusions:
- Autologous adult stem cell therapy, alone or with revascularization, shows encouraging results.
- Further translational research is warranted to optimize cell therapy protocols and elucidate underlying mechanisms.
- Novel cell populations may offer future therapeutic advancements.
Introduction:
Cardiovascular disease is a major cause of death worldwide. Different medical and surgical therapeutic options are well established, but a significant number of patients are not amenable to standard therapeutic options. Cell-based therapies after clinical application have shown different results in recent years. Here, we are giving a comprehensive overview on major available clinical data regarding cell therapy.
Background:
Cell-based therapies and tissue engineering provide new promising platforms to develop upcoming therapeutic options. Initial clinical trials were able to generate promising results. A variety of different stem cell types have been used for the clinical application. Different adult cardiac stem cells and progenitor cells, including mesenchymal, CD34(+) and CD133(+) autologous human bone marrow-derived stem cells (BMCs), human myoblasts, and peripheral blood-derived stem and progenitor cells (PBSCs) have been used for the therapy for end-stage heart failure. Future experiments will show the importance of novel cell populations and clarify the mechanism causing cell therapy-mediated observed effects.
Conclusion:
Several clinical trials have reported on sole therapy, as well as combined application of autologous adult stem cells with conventional revascularization. The reported promising findings encourage further research in the field of the translational research.
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