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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

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[Multiple familial "eruptive" dermatofibromas].

M Marque¹, V Pallure, P Huet

¹Service de dermatologie, université Montpellier 1, hôpital Saint-Éloi, CHU, 80, avenue Auguste-Fliche, 34295 Montpellier, France. myriammarque@yahoo.fr

Annales De Dermatologie Et De Venereologie

|June 19, 2013

Summary

This summary is machine-generated.

Multiple eruptive dermatofibromas (DF) are rare skin tumors. This study presents a rare familial case of disseminated DF, highlighting its infrequent genetic occurrence.

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Area of Science:

Dermatology
Oncology
Genetics

Background:

Multiple eruptive dermatofibromas (DF) are uncommon benign cutaneous neoplasms.
DF are typically associated with immune deficiency, neoplastic diseases, or immunosuppressive therapy.
Familial cases of multiple DF are exceptionally rare.

Observation:

A 79-year-old woman and her 37-year-old daughter presented with disseminated DF over several decades.
Neither patient had a history of conditions or treatments linked to multiple DF.
Family history revealed similar lesions in other relatives.

Findings:

The study identified a rare familial occurrence of multiple eruptive dermatofibromas.
The affected family members presented with disseminated DF without typical associated risk factors.
This case underscores the potential for genetic predisposition in some DF cases.

Implications:

The findings suggest that genetic factors may play a role in the development of multiple eruptive DF.
Recognizing familial DF is crucial for accurate diagnosis and genetic counseling.
Further research into the genetic basis of DF could elucidate underlying mechanisms.