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Updated: May 10, 2026

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Published on: November 4, 2016
Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells
Shaukat Ali Khan1, Johannes Nowatzky1,2, Sonia Jiménez-Branda1
1New York University School of Medicine, Cancer Institute, Smilow Research Building 1303, 522 First Avenue, New York, NY 10016, U.S.A.
Objective:
The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus.
Methods:
Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI ≥ 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation.
Results:
The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality.
Conclusion:
cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.
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