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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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[Association study between PDE4D gene polymorphism and ischemic stroke].

Kuo Liu1, Jin-wei Wang, Zhi-ping Yu

  • 1Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

This study investigated the PDE4D gene

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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

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Published on: November 14, 2017

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Neurology

Background:

  • Ischemic stroke is a leading cause of disability and mortality.
  • Genetic factors play a significant role in ischemic stroke susceptibility.
  • The phosphodiesterase 4D (PDE4D) gene has been implicated in cardiovascular traits.

Purpose of the Study:

  • To examine the association and linkage of the rs966221 polymorphism in the PDE4D gene with ischemic stroke.
  • To investigate the relationship between rs966221 and ischemic stroke-related traits, including carotid intima media thickness (cIMT), apolipoprotein B (apoB), high-sensitivity C-reactive protein (hs-CRP), and blood pressure.

Main Methods:

  • Recruitment of 276 ischemic stroke families (776 participants).
  • Application of Generalized Estimating Equation (GEE) to account for within-family correlations.
  • Utilized non-parametric linkage analysis and Family-Based Association Test (FBAT) to assess genetic associations.

Main Results:

  • The rs966221 C allele showed association with cIMT (P=0.019) in a dominant model.
  • Significant associations were found between rs966221 genotypes (TT, CT) and cIMT.
  • Linkage evidence for rs966221 was observed with apoB (P<0.001), hs-CRP (P=0.003), and systolic blood pressure (P=0.036).

Conclusions:

  • Abnormalities in serum lipids, blood pressure, and increased cIMT are linked to ischemic stroke.
  • The rs966221 polymorphism in the PDE4D gene may be associated with cIMT.
  • Linkage of rs966221 with apoB, hs-CRP, and systolic blood pressure suggests a role in stroke pathogenesis.