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A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
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Published on: January 17, 2011

Outcome of intubate surfactant rapidly extubate (InSuRE): an Indian experience

Amit Tagare1, Sandeep Kadam, Umesh Vaidya

  • 1Division of Neonatology, Department of Pediatrics, KEM Hospital, Rasta Peth, Pune, India, docamikast@gmail.com.

Indian Journal of Pediatrics
|June 19, 2013
PubMed

Insights

The Intubation, Surfactant and Rapid Extubation (InSuRE) method showed feasibility for preterm neonates with respiratory distress syndrome (RDS). Further multicentric trials are needed to confirm safety and efficacy in developing countries.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Critical Care

Background:

  • Respiratory distress syndrome (RDS) is a common condition in preterm neonates.
  • Effective management strategies are crucial for improving outcomes in preterm infants.

Purpose of the Study:

  • To evaluate the outcome of the InSuRE (Intubation, Surfactant and Rapid Extubation) protocol.
  • To assess the feasibility of InSuRE in managing preterm neonates with RDS.

Main Methods:

  • Preterm neonates meeting inclusion criteria were enrolled after informed parental consent.
  • The primary outcome was the proportion of neonates achieving success or failure with the InSuRE protocol.
  • Success criteria for InSuRE were predefined.

Main Results:

  • Out of 28 neonates, 16 (57%) successfully underwent InSuRE.
  • Successful InSuRE was associated with lower birth weight and earlier initiation of nasal continuous positive airway pressure (nCPAP) and surfactant administration.
  • Two deaths occurred in the successful group due to neonatal sepsis, while none occurred in the failure group.

Conclusions:

  • The InSuRE protocol is feasible for managing preterm neonates with RDS in developing countries.
  • Larger multicentric randomized controlled trials are necessary to establish the safety and efficacy of InSuRE in these settings.
Abstract

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