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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

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Related Experiment Video

Updated: May 10, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Transplantation tolerance.

Colin Brinkman1, Bryna Burrell, Joseph Scalea

  • 1Departments of Surgery and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.

Methods in Molecular Biology (Clifton, N.J.)
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

Achieving graft-specific tolerance without immunosuppression requires understanding tolerance mechanisms and overcoming barriers. Future research needs assays to confirm tolerance and biomarkers for better matching and monitoring.

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Last Updated: May 10, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Area of Science:

  • Transplantation immunology
  • Immunosuppression therapy
  • Graft survival

Background:

  • Graft tolerance is defined as graft-specific survival without ongoing immunosuppression.
  • Central and peripheral tolerance mechanisms are crucial for graft acceptance.
  • Current limitations exist in achieving and confirming graft-specific tolerance.

Purpose of the Study:

  • To review mechanisms of central and peripheral tolerance.
  • To discuss barriers and limitations in achieving graft-specific tolerance.
  • To highlight the need for definitive laboratory assays for tolerance assessment.

Main Methods:

  • Review of existing literature on transplantation tolerance.
  • Discussion of immunological mechanisms underlying tolerance.
  • Analysis of current challenges and future directions in tolerance induction.

Main Results:

  • Understanding of central and peripheral tolerance mechanisms is essential.
  • Significant barriers and limitations hinder the achievement of graft-specific tolerance.
  • Definitive laboratory assays are currently lacking to confirm a tolerant state.

Conclusions:

  • Graft-specific tolerance is a complex immunological state.
  • Overcoming barriers requires further research into tolerance mechanisms.
  • Development of reliable biomarkers and assays is critical for clinical application.