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Updated: May 10, 2026
16:49
Multifocal Electroretinograms
Published on: December 4, 2011
[Update of multifocal motor neuropathy]
Naoko Matsui1, Ai Miyashiro, Ryuji Kaji
1Department of Neurology, Institute of Health Bioscience, Tokushima University Graduate School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 20, 2013
Summary
Multifocal motor neuropathy (MMN) is rare in Japan, with a prevalence of 0.3 per 100,000. Intravenous immunoglobulin effectively treated MMN patients, showing significant clinical improvement.
Area of Science:
- Neurology
- Epidemiology
Context:
- Retrospective study comparing Multifocal Motor Neuropathy (MMN) and Amyotrophic Lateral Sclerosis (ALS) patients in Japan.
- Data collected from major Japanese neuromuscular centers between 2005 and 2009.
Purpose:
- To determine the prevalence of MMN in comparison to ALS in Japan.
- To evaluate the diagnostic marker of conduction block (CB) in MMN.
- To assess the efficacy of intravenous immunoglobulin (IVIg) treatment in MMN patients.
Summary:
- The study included 47 MMN patients and 1,051 ALS patients.
- The MMN to ALS ratio varied but averaged 0.05, with an estimated MMN prevalence of 0.3 per 100,000.
- Conduction block was observed in 56.5% of MMN patients, and 75.6% showed clinical improvement after IVIg therapy.
Impact:
- Provides crucial epidemiological data on MMN prevalence in Japan.
- Highlights the diagnostic utility of conduction block in MMN.
- Confirms the effectiveness of IVIg as a treatment for MMN, aiding clinical management.
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