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Updated: Mar 11, 2026

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis
Published on: June 23, 2022
[Immune Cells and Proteins Associated with Disease Progression in Amyotrophic Lateral Sclerosis: New Insights from
Koji Fujita1, Naoko Matsui, Yuishin Izumi
1Department of Neurology, Tokushima University Graduate School of Biomedical Sciences.
Abstract:
Disease progression in amyotrophic lateral sclerosis shows substantial individual variability, and immune mechanisms have attracted attention as underlying factors. Immune profiles associated with disease progression were identified using cytokine profiling, proteomics, and single-cell analyses. Peripheral blood mononuclear cells, such as Th17 cells and effector CD8+ T cells, along with inflammation-related proteins, including interleukin-17A and CD94, are associated with disease progression. This review summarizes the findings of multi-omics studies.
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