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Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology
Published on: August 23, 2024
Aqueous and hydro-alcoholic media effects on polyols
Kofi Asare-Addo1, Barbara R Conway1, Mohamed J Hajamohaideen1
1Pharmacy and Pharmaceutical Science, University of Huddersfield, Huddersfield, HD1 3DH, United Kingdom.
Colloids and Surfaces. B, Biointerfaces
|June 20, 2013
Summary
This study explored how polyols affect drug release from extended-release (ER) tablets when combined with alcohol. Maltitol-based ER tablets showed resilience to ethanol, suggesting careful polyol selection is key for robust drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Alcohol consumption with oral medications can alter drug levels, posing safety risks.
- The Food and Drug Agency (FDA) highlighted risks associated with alcohol-drug interactions, leading to interest in alcohol-resistant drug formulations.
- Extended-release (ER) drug delivery systems require matrices robust against external factors like alcohol.
Purpose of the Study:
- To investigate the influence of polyols as diluents on the compaction properties and drug release characteristics of HPMC-based ER matrices.
- To evaluate the impact of varying ethanol concentrations on the in vitro drug release profiles of theophylline from polyol-containing ER tablets.
- To determine the robustness of maltitol-based ER matrices against hydro-alcoholic dissolution media.
Main Methods:
- Polyols (erythritol, xylitol, mannitol, maltitol) were used as diluents in HPMC matrices with theophylline.
- Tablet compaction properties were assessed.
- In vitro drug release studies were conducted using dissolution media at pH 1.2 and 6.8 with ethanol concentrations ranging from 5% to 40% (v/v).
- Drug release profiles were analyzed using similarity factors (f2).
Main Results:
- Increasing hydroxyl groups in polyols enhanced tablet strength and reduced theophylline release rates.
- Maltitol-based ER tablets demonstrated resilience to ethanol (5-40%) at pH 1.2 (f2=57-74).
- At pH 6.8, maltitol formulations showed reduced resilience to ethanol (f2=36-48), with no significant difference in drug release above 5% alcohol concentration.
Conclusions:
- Polyol selection significantly impacts the compaction and drug release properties of ER matrices.
- Maltitol-based matrices offer a degree of robustness against ethanol, particularly at acidic pH.
- Careful consideration of polyol choice is crucial for developing alcohol-resistant ER drug delivery systems.
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