Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Refining the Surgical Necrotizing Enterocolitis Protocol: Impact of Clinical Factors on Laparotomy Risk.

The Journal of surgical research·2026
Same author

Simulation Enhances Resident Preparedness Using Skin Cell Suspension Autograft.

European burn journal·2026
Same author

Crawl, Walk Fast, Run Hard: Military-Civilian Partnership Training at the Army Trauma Training Course Improves Perceived Deployment Readiness.

Military medicine·2026
Same author

Two for One? Safety and Efficacy of Concomitant Hernia Repair During Pediatric Appendectomy.

The Journal of surgical research·2026
Same author

Sex-based differences in post-injury behavioral health readmissions among adolescents hospitalized for firearm injuries.

American journal of surgery·2026
Same author

Substance use and mental health disorders in pediatric firearm trauma.

Journal of pediatric surgery·2026
Same journal

The impact of fathers and male role models on recovery and resilience in pediatric victims of violent trauma.

The journal of trauma and acute care surgery·2026
Same journal

Peptidyl arginine deiminase 2 (PAD2) inhibition is associated with acute and long-term benefits in a murine model of traumatic brain injury.

The journal of trauma and acute care surgery·2026
Same journal

CT-first resuscitation for severe blunt trauma: A propensity score-matched cohort study.

The journal of trauma and acute care surgery·2026
Same journal

The intravenous targeted nanopeptide, CAQK, is neuroprotective and improves motor function after spinal cord injury in rats.

The journal of trauma and acute care surgery·2026
Same journal

Authors' reply to the Letter to the Editor on "Use of extracorporeal membrane oxygenation in traumatic injuries with acute respiratory distress syndrome: A systematic review and meta-analysis".

The journal of trauma and acute care surgery·2026
Same journal

Characteristics and time course of postconcussive symptoms in children and adolescents with moderate to severe extracranial trauma with and without mild traumatic brain injury.

The journal of trauma and acute care surgery·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Hypercoagulability after burn injury.

Robert M Van Haren1, Chad M Thorson, Evan J Valle

  • 1Division of Trauma, the Dewitt-Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Ryder Trauma Center, Miami, Florida 33136, USA.

The Journal of Trauma and Acute Care Surgery
|June 20, 2013
PubMed
Summary
This summary is machine-generated.

Burn patients typically have normal coagulation upon admission but develop hypercoagulability during recovery. Early hypercoagulability may indicate an increased risk of venous thromboembolism (VTE).

More Related Videos

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
08:40

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Related Experiment Videos

Last Updated: May 10, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
08:40

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Area of Science:

  • Trauma and injury research
  • Hematology and coagulation disorders
  • Burn medicine

Background:

  • Hypercoagulability is a known response to trauma.
  • Limited data exists on coagulation changes specifically after burn injuries.
  • This study investigated coagulation status in burn patients.

Purpose of the Study:

  • To test the hypothesis that burn patients exhibit hypercoagulability upon admission and/or during recovery.
  • To identify potential risk factors for hypercoagulability and venous thromboembolism (VTE) in burn patients.

Main Methods:

  • Prospective observational trial at a verified Burn Center.
  • Thromboelastography (TEG) and routine coagulation tests performed on admission and weekly.
  • Analysis included comparisons between burn types, sexes, and inhalational injury presence.

Main Results:

  • Burn patients showed increased hypercoagulability during recovery compared to admission.
  • Fibrinogen and natural anticoagulation proteins (protein C, S, antithrombin III) were elevated.
  • Patients with hypercoagulable parameters at admission had a higher risk of VTE, despite thromboprophylaxis.

Conclusions:

  • Burn patients generally present with normal coagulation but develop hypercoagulability during recovery.
  • Hypercoagulability at admission may predict an increased risk of VTE.
  • Consideration for enhanced monitoring or thromboprophylaxis in at-risk burn patients is suggested.