Related Experiment Video
Updated: May 10, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
SLC classification: an update
A Schlessinger1, S W Yee, A Sali
1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA. avner.schlessinger@mssm.edu
Abstract:
The 386 human SLC superfamily members are diverse in sequence, structure, and function. Using sequence similarity, we previously classified the SLC superfamily members and identified relationships among families. With the recent determination of new SLC structures and identification of previously unknown human SLC families, an update of our previous classification is timely. Here, we comprehensively compare the SLC sequences and structures and discuss the applicability of structure-based ligand discovery to key SLC members.
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