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SLC classification: an update.

A Schlessinger1, S W Yee, A Sali

  • 1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA. avner.schlessinger@mssm.edu

Clinical Pharmacology and Therapeutics
|June 20, 2013
PubMed
Summary
This summary is machine-generated.

This study updates the classification of the human solute carrier (SLC) superfamily, revealing new families and relationships. It also explores using SLC structures for drug discovery.

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Area of Science:

  • Biochemistry
  • Genomics
  • Structural Biology

Background:

  • The human solute carrier (SLC) superfamily comprises 386 members with diverse functions.
  • Previous classifications relied on sequence similarity, identifying inter-family relationships.
  • Recent discoveries of new SLC structures and families necessitate an updated classification.

Purpose of the Study:

  • To comprehensively compare human SLC sequences and structures.
  • To update the existing classification of the SLC superfamily.
  • To assess the potential of structure-based ligand discovery for key SLC members.

Main Methods:

  • Sequence similarity analysis.
  • Structural comparison of SLC proteins.
  • Identification of novel SLC families.

Main Results:

  • A revised classification of the human SLC superfamily.
  • Identification of previously unknown human SLC families.
  • Insights into the structural diversity and functional relationships within the SLC superfamily.

Conclusions:

  • The updated SLC classification provides a foundation for further research.
  • Structure-based ligand discovery holds promise for targeting SLCs.
  • This work facilitates a deeper understanding of SLC-mediated transport.