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Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...

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Related Experiment Video

Updated: May 10, 2026

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
11:26

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow

Published on: August 14, 2014

Endothelial adherens junctions at a glance.

Elisabetta Dejana1, Fabrizio Orsenigo

  • 1IFOM, Foundation FIRC Institute of Molecular Oncology, Milan, Italy. elisabetta.dejana@ifom.eu

Journal of Cell Science
|June 20, 2013
PubMed
Summary

Adherens junctions control vascular permeability. Disruptions in these cell junctions, like in cerebral cavernous malformation, lead to fragile, hemorrhagic vessels and disease.

Area of Science:

  • Cell Biology
  • Vascular Biology
  • Biochemistry

Background:

  • Adherens junctions are crucial for cell-to-cell adhesion and signal transduction.
  • VE-cadherin (CDH5/CD144) is the primary endothelial adherens junction protein, vital for vascular integrity.
  • Variations in endothelial cell junctions exist across different vessel types.

Purpose of the Study:

  • To explore the role of adherens junctions in regulating vascular permeability.
  • To highlight how adherens junction dysfunction contributes to vascular pathologies.
  • To use cerebral cavernous malformation (CCM) as a model for junctional defects.

Main Methods:

  • Review of existing literature on adherens junctions and vascular biology.
  • Analysis of molecular mechanisms underlying cell adhesion and signaling.

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Published on: March 21, 2014

Micropatterning and Assembly of 3D Microvessels
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Micropatterning and Assembly of 3D Microvessels

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Related Experiment Videos

Last Updated: May 10, 2026

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
11:26

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow

Published on: August 14, 2014

A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
11:38

A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress

Published on: March 21, 2014

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

  • Case study examination of cerebral cavernous malformation.

    • Main Results:

    • Modifications in adherens junction components alter vascular permeability.
    • Dismantled adherens junctions in CCM lead to loss of endothelial polarity and vessel fragility.
    • Altered vascular morphology and permeability are observed in diseases like tumors.

    Conclusions:

    • Adherens junctions are key regulators of vascular permeability and integrity.
    • Defects in adherens junctions can cause serious vascular malformations and diseases.
    • Further understanding of junctional integrity is essential for developing new therapies for vascular disorders.