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[Enzyme liberation after electrical His bundle ablation].

L Junker1, C Wagenknecht, D Pfeiffer

  • 1Zentralinstitut für Herz-Kreislauf-Forschung, Akademie der Wissenschaften der DDR Berlin-Buch.

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|April 15, 1990
PubMed
Summary
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Cardiac enzyme release, including aspartate aminotransferase (ASAT) and lactic dehydrogenase (LDH), increases with energy during His bundle ablation. This release pattern helps estimate myocardial necrosis size post-ablation.

Area of Science:

  • Biochemistry
  • Cardiology
  • Enzymology

Context:

  • His bundle ablation is an electrophysiological procedure.
  • Assessing myocardial injury post-ablation is crucial.

Purpose:

  • To investigate the release of specific cardiac enzymes and isoenzymes following His bundle ablation.
  • To correlate enzyme release with applied energy levels and estimate myocardial necrosis.

Summary:

  • The study monitored the release of aspartate aminotransferase (ASAT), lactic dehydrogenase (LDH), malic dehydrogenase (MDH), and creatine kinase (CK) after His bundle ablation.
  • Enzyme levels increased proportionally to the energy used during the procedure.
  • Mitochondrial enzymes (MDH and ASAT) were detected in most patients, suggesting their utility.

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Impact:

  • The sequential release pattern of these enzymes and isoenzymes can serve as a biomarker for quantifying the extent of myocardial necrosis.
  • Provides a method for assessing ablation-induced cardiac tissue damage.