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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Markings01:26

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

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Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

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Bone turnover markers.

Penelope Coates1

  • 1Chemical Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia. penelope.coates@health.sa.gov.au

Australian Family Physician
|June 20, 2013
PubMed
Summary
This summary is machine-generated.

Bone remodelling is a continuous process essential for calcium balance and repairing microdamage. This vital skeletal function ensures bone health and structural integrity throughout life.

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Area of Science:

  • Skeletal Biology
  • Bone Physiology
  • Calcium Homeostasis

Background:

  • Bone undergoes continuous remodeling to maintain skeletal integrity.
  • This process is crucial for meeting the body's calcium demands.
  • Microscopic damage within bone tissue necessitates repair mechanisms.

Purpose of the Study:

  • To elucidate the dynamic nature of bone remodeling.
  • To quantify the extent of skeletal involvement in remodeling.
  • To understand the physiological significance of bone turnover.

Main Methods:

  • Utilized established bone physiology principles.
  • Analyzed data on skeletal replacement rates.
  • Assessed the percentage of bone undergoing remodeling.

Main Results:

  • The adult skeleton is entirely replaced approximately every 10 years.
  • Approximately 10% of the skeletal mass is actively involved in remodeling at any given time.
  • Bone remodeling is a constant and significant physiological process.

Conclusions:

  • Bone remodeling is a fundamental and ongoing process in adult skeletal maintenance.
  • The rate of skeletal turnover highlights the dynamic nature of bone.
  • Continuous remodeling ensures both structural repair and mineral homeostasis.