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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Cytotoxic dibenzocyclooctadiene lignans from Kadsura coccinea
Qing-Jie Zhao1, Yan Song, Hai-Sheng Chen
1Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China, qjzhao@smmu.edu.cn.
Abstract:
Three new dibenzocyclooctadiene lignans, kadusurain A-C (1-3), together with two known compounds kadsuphilin A (4) and B (5), were isolated from an EtOAc fraction of the 80 % acetone extract of Kadsura coccinea (Lem.) A. C. Smith. Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy. Anti-proliferative effect of isolated compounds was evaluated against four human tumor cell lines (A549, HCT116, HL-60, and HepG2), and it was found that compound 1 exhibited significant antiproliferative effects with IC50 values ranging from 1.05 to 12.56 μg/ml.
