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Updated: May 10, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Epithelial to mesenchymal transition-the roles of cell morphology, labile adhesion and junctional coupling
Tariq Abdulla1, Luis Luna-Zurita, José Luis de la Pompa
1School of Electronic, Electrical and Systems Engineering, Loughborough University, Loughborough, UK. T.Abdulla@lboro.ac.uk
Abstract:
Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.
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