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Updated: May 10, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics

K Nho1, J J Corneveaux, S Kim

  • 1Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.

Molecular Psychiatry
|June 22, 2013
PubMed
Abstract

No abstract available in PubMed .

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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