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Molecularly imprinted solid-phase extraction for selective trace analysis of trifluoperazine.

Abdol Mohammad Attaran1, Narges Mohammadi2, Mehran Javanbakht3

  • 1Department of Chemistry, Payame Noor University, Delijan, Iran amohammadattaran@gmail.com mehranjavanbakht@gmail.com.

Journal of Chromatographic Science
|June 22, 2013
PubMed
Summary

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A new molecularly imprinted solid-phase extraction method efficiently determines trifluoperazine (TFP) in biological samples. This technique offers high recovery and sensitivity for TFP analysis in serum and urine.

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Pharmacology

Background:

  • Accurate determination of trifluoperazine (TFP) in biological fluids is crucial for therapeutic drug monitoring and pharmacokinetic studies.
  • Existing sample clean-up techniques may lack the specificity or efficiency required for complex biological matrices.
  • Molecularly imprinted polymers (MIPs) offer a promising approach for selective analyte extraction due to their tailored recognition sites.

Purpose of the Study:

  • To develop and validate a novel molecularly imprinted solid-phase extraction (MISPE) technique for the selective determination of trifluoperazine (TFP) in human serum and urine.
  • To evaluate the performance of water-compatible MIPs as a sorbent for TFP extraction.
  • To assess the efficiency, selectivity, and sensitivity of the developed MISPE method.

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Main Methods:

  • Preparation of water-compatible molecularly imprinted polymers (MIPs) using methacrylic acid, ethylene glycol dimethacrylate, chloroform, and TFP as the template molecule.
  • Application of the synthesized MIPs as a solid-phase extraction (SPE) sorbent for TFP extraction from human serum and urine samples.
  • Optimization of various parameters influencing extraction efficiency and evaluation of MIP selectivity against structurally similar compounds.

Main Results:

  • The developed MISPE method demonstrated high extraction efficiency for TFP from both serum and urine samples, with recovery rates exceeding 92% and 93%, respectively.
  • Achieved low limits of detection (LOD) and quantification (LOQ) for TFP in urine (0.06 µg/L and 0.2 µg/L) and serum (0.15 µg/L and 0.4 µg/L).
  • The MIPs exhibited good selectivity, effectively distinguishing TFP from structurally related substances.

Conclusions:

  • The novel MISPE technique utilizing water-compatible MIPs provides a highly selective, sensitive, and efficient method for trifluoperazine determination in biological fluids.
  • This approach is suitable for routine analysis and therapeutic drug monitoring of TFP in clinical settings.
  • The developed MIPs represent a valuable tool for the clean-up and preconcentration of TFP prior to instrumental analysis.