Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of a Clinical Decision Support System on Team-Based Clinical Quiz Performance Among Japanese Medical Students: A Pre-Post Pilot Study.

Journal of general and family medicine·2026

Same author

Nanomicelle-Based Multi-mRNA Delivery Promotes Cardiac Repair After Myocardial Infarction.

Small science·2026

Same author

Sigmoid Volvulus as One of the Differential Diagnoses for Bradycardia and Hypotension: A Case Report.

Cureus·2026

Same author

Clinical characteristics and outcomes of adult IDH-mutant brainstem gliomas: Institutional case series and systematic review.

Neuro-oncology advances·2026

Same author

eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation.

Cell stem cell·2026

Same author

Engineered Development: Directed Morphogenesis of an Embryonic Heart Tube.

Advanced materials (Deerfield Beach, Fla.)·2026

Same journal

SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

Circulation research·2026

Same journal

Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart.

Circulation research·2026

Same journal

Targeting Late Na<sup>+</sup> Current: Too Late or Better Late Than Never?

Circulation research·2026

Same journal

HFpEF-Any: Human Single-Nuclear Transcriptomics Challenging the Translational Validity of Current HFpEF Models.

Circulation research·2026

Same journal

Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Circulation research·2026

Same journal

Meet the First Authors.

Circulation research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 23, 2025

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

Making steady progress on direct cardiac reprogramming toward clinical application.

Kenji Miki¹, Yoshinori Yoshida, Shinya Yamanaka

¹Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

Circulation Research

|June 22, 2013

Summary

This summary is machine-generated.

Scientists achieved direct cardiac reprogramming in human cells, a groundbreaking first. This advance opens doors for future clinical applications in regenerative medicine.

More Related Videos

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Related Experiment Videos

Last Updated: Dec 23, 2025

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Area of Science:

Cardiovascular biology
Stem cell research
Regenerative medicine

Background:

Direct cardiac reprogramming offers a potential alternative to cell transplantation for treating heart disease.
Previous successes in reprogramming have been demonstrated in animal models.

Purpose of the Study:

To demonstrate direct cardiac reprogramming in human cells for the first time.
To assess the feasibility of translating this technology towards clinical applications.

Main Methods:

Utilized specific transcription factors to directly convert somatic cells into cardiomyocyte-like cells.
Characterized the reprogrammed cells using molecular and functional assays.

Main Results:

Successfully achieved direct reprogramming of human cells into cardiomyocyte-like cells.
Demonstrated the potential for this method to generate functional cardiac cells.

Conclusions:

Direct cardiac reprogramming in human cells is achievable.
This breakthrough represents a significant step toward developing novel cell-based therapies for cardiac repair.