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Ciprofloxacin Resistance in Enterococcus faecalis Strains Isolated From Male Patients With Complicated Urinary Tract

Gilho Lee1

  • 1Department of Urology, Dankook University College of Medicine, Cheonan, Korea.

Korean Journal of Urology
|June 22, 2013
PubMed
Abstract

Insights

Ciprofloxacin resistance is high in Enterococcus faecalis causing complicated urinary tract infections (UTIs) in men. Hospital-acquired infections and urological department treatment increase resistance risk, suggesting alternative therapies like ampicillin/sulbactam.

Area of Science:

  • Infectious Diseases
  • Urology
  • Microbiology

Background:

  • Urinary tract infections (UTIs) are common bacterial infections.
  • Fluoroquinolones, including ciprofloxacin, are standard UTI treatments.
  • Enterococcal UTIs and fluoroquinolone resistance patterns require further investigation.

Purpose of the Study:

  • To assess antimicrobial susceptibility of Enterococcus faecalis strains.
  • To identify risk factors for ciprofloxacin resistance in complicated UTIs.
  • To evaluate E. faecalis isolates from male patients in a Korean teaching hospital.

Main Methods:

  • Analysis of 81 E. faecalis strains from male UTI patients over 3 years.
  • Antimicrobial susceptibility testing using the Vitek 2 automated system.
  • Risk factor analysis comparing resistant and susceptible strains.

Main Results:

  • High resistance rates observed for ciprofloxacin (47%), levofloxacin (46%), and norfloxacin (58%).
  • E. faecalis showed >90% resistance to erythromycin and tetracycline.
  • Hospital-acquired infection, urological department treatment, and transfer from healthcare centers were significant risk factors for ciprofloxacin resistance.

Conclusions:

  • Ciprofloxacin is not recommended for complicated UTIs caused by E. faecalis in men with identified risk factors.
  • Ampicillin/sulbactam is a potential alternative for treating ciprofloxacin-resistant E. faecalis UTIs in Korea.
  • Understanding resistance patterns is crucial for effective UTI management.
Keywords:
CiprofloxacinDrug resistanceEnterococcus faecalisUrinary tract infection

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