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[Apoptosis-reactivating agents for targeted anticancer therapy]

A A Fil'chenkov

    Biomeditsinskaia Khimiia
    |June 25, 2013
    PubMed

    Insights

    This study reviews apoptosis pathways and their role in cancer cell survival. It highlights novel anticancer drugs that reactivate apoptosis and methods for visualizing therapy-induced cell death.

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Cancer Biology

    Context:

    • Apoptosis, or programmed cell death, is crucial for development and tissue homeostasis.
    • Dysregulation of apoptosis contributes to cancer cell survival and resistance to therapy.
    • Understanding apoptosis mechanisms is key to developing effective cancer treatments.

    Purpose:

    • To present current knowledge on the molecular mechanisms of apoptosis, including extrinsic and intrinsic pathways.
    • To discuss the role of apoptotic pathway dysregulation in cancer chemoresistance and radioresistance.
    • To survey novel therapeutic strategies targeting apoptosis and methods for visualizing therapy-induced cell death.

    Summary:

    • The extrinsic death receptor and intrinsic mitochondrial pathways of apoptosis are detailed.
    • Cancer cells evade apoptosis, leading to treatment resistance.
    • New anticancer drugs aim to selectively induce apoptosis in malignant cells, with some in clinical trials.
    • Non-invasive in vivo imaging techniques for monitoring therapy-induced apoptosis are reviewed.

    Impact:

    • Provides a comprehensive overview of apoptosis in cancer biology.
    • Identifies promising therapeutic targets and strategies for cancer treatment.
    • Highlights advancements in visualizing treatment response in vivo.
    • Informs future research on apoptosis-modulating cancer therapies.

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