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Updated: May 10, 2026
In vivo Measurement of Knee Extensor Muscle Function in Mice
Published on: March 4, 2021
Responses of knee extensor muscles to leg press training of various types in human
A Netreba1, D Popov, Ya Bravyy
1Russian Federation State Research Center, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow 123007, Khoroshevskoe Sh., 76A, Russia. anetreba@yandex.ru
Abstract:
Responses of m. vastus lateralis to 8-week resistive training of various types at leg press mashine were investigated in 30 male subjects. Training loads were 25, 65 and 85% of one repetition maximum for low (LI), medium (MI), and high intensity (HI) training groups respectively, while angular velocities of contraction differed considerably between groups. The total work done during training session was identical. The maximum strengths during isokinetic knee extension in LI and HI groups were increased at most angular velocities. In group MI increments were obtained only during concentric contractions. Significant improvement of fatigue resistance and maximum oxygen consumption (V(O2max)) was seen only in group MI and LI, respectively. The training-related increase of cross-sectional area in type II fibers in m. vastus lateralis was in the order of HI > MI > LI group, and that of type I fibers was opposite. The increased myonuclear number was found for HI group. The data suggest that fiber hypertrophy, fatigue resistance and V(O2max) changes were related to the type of training.
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