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Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?
Claire Lugassy1, Bruno Péault, Madhuri Wadehra
1Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA.
Pigment Cell & Melanoma Research
|June 25, 2013
Abstract:
We hypothesize that the interaction between angiotropic melanoma cells and the abluminal vascular surface can induce or sustain embryonic and/or stem cell migratory properties in these tumor cells. As a result, such angiotropic melanoma cells may migrate along the abluminal vascular surface, demonstrating pericytic mimicry. Through these cellular interactions, melanoma cells may migrate toward secondary sites.

