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Computational approaches for predicting the binding sites and understanding the recognition mechanism of protein-DNA

M Michael Gromiha1, R Nagarajan

  • 1Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India. gromiha@iitm.ac.in

Advances in Protein Chemistry and Structural Biology
|June 25, 2013
PubMed

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Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Conserved Binding Sites01:49

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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