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Related Experiment Video

Updated: May 10, 2026

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

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Acute lumbosacral transverse myelitis.

Takao Hashimoto¹, Kosuke Naito

¹Department of Neurology, Aizawa Hospital, 2-5-1 Honjo, Matsumoto 390-8510, Japan.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|June 25, 2013

Summary

Idiopathic acute lumbosacral myelitis is rare. Prompt steroid therapy can halt symptom progression and improve outcomes for patients with this condition.

Keywords:

Acute transverse myelitis Lumbosacral spinal cord Spinal cord Steroid Urinary retention

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Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

Published on: February 24, 2026

Area of Science:

Neurology
Immunology

Background:

Idiopathic acute lumbosacral myelitis is a rare neurological disorder.
It presents with lower extremity weakness, sensory loss, and urinary dysfunction.

Observation:

Two patients with idiopathic acute lumbosacral myelitis presented with specific neurological deficits.
Symptoms included urinary retention, motor/sensory paresis, anogenital sensory loss, and reduced reflexes.

Findings:

Early intervention with high-dose steroid pulse therapy (within 2 days of onset) halted symptom progression in both patients.
Despite treatment, residual sensory deficits and urinary retention impacted daily functioning.

Implications:

Immediate immunosuppressive therapy, particularly high-dose steroids, is crucial for improving prognosis in acute lumbosacral transverse myelitis.
Timely diagnosis and treatment are essential to mitigate long-term neurological sequelae.