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Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation

Xi Chen1, Qizhi Qin, Wenjuan Zhang

  • 1Department of Occupational and Environmental Health, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 25, 2013
PubMed

Keywords:
40S ribosomal protein S6 kinase8-OHdG8-hydroxy-2′-deoxyguanosineAKTDEHPDMSODi-(2-ethylbexyl) phthalateGSHGSSGOxidative stressPI3KPI3K–AKT–mTOR pathwayPPARProliferationROSTBSTbuffered saline with tween 20di-(2-ethylhexyl) phthalatedimethyl sulfoxideglutathionemTORmammalian target of rapamycinoxidized glutathionep70S6Kperoxisome proliferators-activated receptorphosphoinositide 3-kinaseprotein kinase Breactive oxygen species

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