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Related Experiment Video

Updated: May 10, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Circulating and tissue resident endothelial progenitor cells.

David P Basile¹, Mervin C Yoder

¹Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana.

Journal of Cellular Physiology

|June 25, 2013

Summary

This summary is machine-generated.

Identifying endothelial progenitor cells (EPCs) remains controversial due to the lack of a unique marker. This review clarifies EPC identification, derivation, and nomenclature for vascular repair research.

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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

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Last Updated: May 10, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Area of Science:

Cardiovascular Biology
Stem Cell Research
Regenerative Medicine

Background:

Endothelial progenitor cells (EPCs) are crucial for vascular repair.
Over a decade of research has not yielded a unique marker for EPC identification.
Existing markers and criteria for EPCs remain debated.

Purpose of the Study:

To review the fundamental criteria for identifying endothelial progenitor cells (EPCs).
To provide an overview of methods for EPC derivation, expansion, and enumeration.
To propose nomenclature changes for clarity in vascular repair research.

Main Methods:

Literature review of studies on endothelial progenitor cells.
Analysis of methods for cell derivation, expansion, and enumeration.
Discussion of circulating and resident vascular cells.

Main Results:

No single unique marker definitively identifies endothelial progenitor cells.
Various methods exist for studying EPCs, with ongoing debate on their efficacy.
Circulating and resident vascular cells play roles in vascular repair.

Conclusions:

Clarifying EPC identification is essential for advancing vascular repair understanding.
Standardized nomenclature is needed to demystify the cellular elements involved in vascular repair.
Further research is required to establish definitive EPC markers and criteria.