Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital anosmia.

B W Jafek1, A S Gordon, D T Moran

  • 1Department of Otolaryngology, Head and Neck Surgery, University of Colorado School of Medicine, Denver.

Ear, Nose, & Throat Journal
|May 1, 1990
PubMed
Summary

Patients with congenital anosmia lack olfactory epithelium, suggesting developmental degeneration. This condition is often isolated, not associated with syndromes like Kallmann

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network.

Clinical pharmacology and therapeutics·2016
Same author

Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.

Clinical pharmacology and therapeutics·2014
Same author

Manual artificial respiration.

What's new·2014
Same author

Adsorption mediated decrease in the biodegradation rate of organic compounds.

Microbial ecology·2013
Same author

The adrenal gland and phagocytosis in the spleen.

Federation proceedings·2010
Same author

Antihormone reactions to blood, urinary and pituitary gonadotrophins.

Federation proceedings·2010

Area of Science:

  • Otolaryngology
  • Developmental Biology
  • Genetics

Background:

  • Congenital anosmia is the absence of the sense of smell from birth.
  • Understanding the underlying pathology is crucial for diagnosis and potential treatments.

Observation:

  • Seven patients with congenital anosmia were evaluated.
  • Biopsies of the olfactory region were performed on these patients.

Findings:

  • No olfactory epithelium was detected in any biopsy specimens.
  • This indicates a complete absence of olfactory epithelium in individuals with congenital anosmia.

Implications:

  • The olfactory placode may form but subsequently degenerate, being replaced by respiratory epithelium.
  • Congenital anosmia is frequently an isolated symptom, with Kallmann's syndrome being a rare association.