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Updated: May 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Fit and motivated: outcome predictors in patients starting a program for lifestyle change
Barbara Cresci1, Giovanni Castellini, Laura Pala
1Endocrinology Unit, AOU Careggi, Florence, Italy.
Background:
In previous pilot studies we have demonstrated that the Treatment Motivation and Readiness Test (TRE-MORE) is capable of predicting the outcome of obesity therapy and that a higher muscle mass (MM) is associated with a greater weight loss. Purposes of the present study were: to confirm the predictive value of TRE-MORE scores and MM, using a standardized non-pharmacologic intervention for weight loss; to explore the relationship between TRE-MORE and MM; to discriminate predictors of attendance from predictors of final therapeutic success.
Methods:
A consecutive series of 331 patients was enrolled and addressed to a standardized treatment protocol.
Results:
Mean weight loss at 6 months was -5.03%. Among participants, 48.7% lost at least 5% initial body weight after 6 months and had significantly higher TRE-MORE total scores and MM. Weight loss was significantly associated with baseline MM, TRE-MORE-3, and a lower number of previous diets. Significantly lower TRE-MORE-3 scores were associated with drop-out.
Conclusion:
The present study confirms that therapeutic success is predicted by TRE-MORE scores and, independently from these, by estimated MM (after adjustment for BMI). TRE-MORE total score is a predictor of failure, but not of attendance, whereas drop-out patients showed a lower score only in TREMORE-3 subscale which investigates lifestyle habits.
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