Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2026

Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography
07:57

Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography

Published on: May 10, 2022

Including spatial information in nonlinear inversion MR elastography using soft prior regularization.

Matthew McGarry, Curtis L Johnson, Bradley P Sutton

    IEEE Transactions on Medical Imaging
    |June 26, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    Magnetic Resonance Imaging01:24

    Magnetic Resonance Imaging

    Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

    Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
    Same author

    SimulScan and Partial Least Squares: Visualizing Swallowing Through Functional and Dynamic Imaging Correlations.

    Magnetic resonance in medicine·2026
    Same author

    A vendor-neutral functional MRI acquisition protocol for multi-site studies.

    Aperture neuro·2026
    Same author

    Mn(II) MRI contrast agents supported by unsymmetric pyridinophane-picolinate ligands.

    Journal of inorganic biochemistry·2026
    Same author

    Multiecho Fat-Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement.

    Magnetic resonance in medicine·2026
    Same author

    The Influence of Blood Lipids on Cerebral Perfusion by Apolipoprotein E Status.

    Journal of lipid research·2026

    This study introduces soft prior regularization (SPR) to magnetic resonance elastography (MRE) for improved mechanical property reconstruction. SPR enhances accuracy by using anatomical information, even for fine tissue structures.

    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Rheology

    Background:

    • Magnetic Resonance Elastography (MRE) relies on tissue displacement data acquired during MRI scans.
    • Anatomical information is often underutilized in MRE reconstruction, limiting accuracy.
    • Prior spatial information integration in MRE is an underexplored area.

    Purpose of the Study:

    • To implement and evaluate soft prior regularization (SPR) for MRE.
    • To leverage anatomical information for enhanced mechanical property reconstruction.
    • To assess SPR's performance in phantom and in vivo experiments.

    Main Methods:

    • Soft Prior Regularization (SPR) was implemented using a penalty term in nonlinear inversion.
    • Homogeneity was enforced within predefined spatial regions.

    Related Experiment Videos

    Last Updated: May 10, 2026

    Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography
    07:57

    Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography

    Published on: May 10, 2022

  • Phantom experiments, simulations, and in vivo scans of human brain tissue were conducted.

    • Main Results:

    • SPR demonstrated stable property value recovery when predefined regions were accurate.
    • Inaccurate segmentation led to bias, which could be mitigated by regularization weighting.
    • Statistically significant differences in viscoelastic properties (storage and loss moduli) were found between frontal lobe gray and white matter in vivo.

    Conclusions:

    • SPR accurately estimates quantitative mechanical properties, even for tissue structures smaller than current MRE resolution.
    • The method is robust to variations in weighting factors when spatial priors are accurate.
    • SPR offers a promising approach for precise mechanical characterization of biological tissues using MRE.