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Ankylosing spondylitis: Chinese perspective, clinical phenotypes, and associated extra-articular systemic features
1Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, No. 5, Fu-Shin St, Kwei-Shan, Tao-Yuan, 33375, Taiwan.
Current Rheumatology Reports
|June 26, 2013
Summary
Ankylosing spondylitis (AS) in China predominantly affects HLA-B27 positive individuals. Chinese AS patients often present with earlier onset, peripheral arthritis, and unique associations like tuberculosis in apical lung disease.
Area of Science:
- Rheumatology
- Epidemiology
- Genetics
Background:
- Ankylosing spondylitis (AS) is a significant rheumatic condition impacting the global population.
- Understanding the epidemiology and clinical nuances of AS in the Chinese population is crucial due to its large size.
Purpose of the Study:
- To review and report the epidemiology of ankylosing spondylitis (AS) in China.
- To detail the specific clinical characteristics of Chinese AS patients.
Main Methods:
- Literature review and epidemiological data analysis.
- Clinical characteristic assessment of Chinese AS patients.
Main Results:
- Over 90% of Chinese AS patients are HLA-B27 positive, primarily the HLA-B*2704 subtype.
- Chinese AS patients exhibit higher rates of juvenile onset, peripheral arthritis, and earlier, recurrent acute anterior uveitis.
- Associated conditions include cardiovascular disorders, metabolic syndrome, and notably, tuberculosis in apical lung disease.
Conclusions:
- The genetic predisposition (HLA-B27) and clinical presentation of AS in China show distinct patterns.
- Early onset, specific extra-articular manifestations, and co-infections like tuberculosis are key features in Chinese AS patients.
