Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Ankle Joint

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Knee Joint

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of hygiene levels in metal-ceramic and stratified zirconia in prosthetic rehabilitation on teeth and implants: a retrospective clinical study of a three-year follow-up.

Journal of biological regulators and homeostatic agents·2021

Same author

Application of the "immunization islands" model to improve quality, efficiency and safety of a COVID-19 mass vaccination site.

Annali di igiene : medicina preventiva e di comunita·2021

Same author

Palatal prosthetic rehabilitation in patients affected by cocaine-induced midline destructive lesions.

Journal of biological regulators and homeostatic agents·2021

Same author

Qualitative evaluation of vomer bone position before and after rapid maxillary expansion: a radiographic study.

Journal of biological regulators and homeostatic agents·2020

Same author

Evaluation of the morphometric covariation between palatal and craniofacial skeletal morphology in class III malocclusion growing subjects.

BMC oral health·2020

Same author

Prosthetic management of patients with oro-maxillo-facial defects: a long-term follow-up retrospective study.

ORAL & implantology·2017

Search research articles

Related Experiment Video

Updated: May 10, 2026

$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

[Charcot osteoarthropathy: don't miss it!].

G Gastaldi¹, J Ruiz, O Borens

¹Service d'endocrinologie, diabétologie et métabolisme, CHUV, 1011 Lausanne. giacomo.gastaldi@chuv.ch

Revue Medicale Suisse

|June 27, 2013

Summary

Charcot neuropathic osteoarthropathy (CNO) is a severe diabetic foot condition. Prompt evaluation and maintaining foot stability are key to preventing deformities and ulceration.

Area of Science:

Diabetic foot complications
Neuropathic osteoarthropathy research
Orthopedic surgery

Background:

Charcot neuropathic osteoarthropathy (CNO) is a serious complication of diabetic peripheral neuropathy.
It leads to significant bone and joint destruction, causing severe deformities and increased morbidity/mortality.

Observation:

Diagnosis relies on identifying inflammatory signs, emphasizing the need for prompt foot evaluation.
Imaging aids in assessing severity but often lacks diagnostic specificity.

Findings:

The primary treatment goal is to achieve and maintain foot and ankle structural stability.
Current evidence does not strongly support bisphosphonates or acute surgical interventions.

Implications:

More Related Videos

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Related Experiment Videos

Last Updated: May 10, 2026

$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Surgery is universally recommended to prevent secondary ulcerations.
Effective management of CNO is crucial for limb salvage in diabetic patients.