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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Environmental control for asthma: recent evidence.

Elizabeth C Matsui¹

¹Johns Hopkins Hospital, CMSC, Baltimore, Maryland 21287, USA. ematsui@jhmi.edu

Current Opinion in Allergy and Clinical Immunology

|June 27, 2013

Summary

This summary is machine-generated.

Environmental control effectively manages asthma, especially in children, by targeting multiple triggers. However, it does not prevent atopic disease development.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Methodology for Sputum Induction and Laboratory Processing

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Published on: December 17, 2017

Area of Science:

Environmental Science
Allergy and Immunology
Public Health

Background:

Asthma management is a significant public health concern.
Environmental factors are known contributors to asthma exacerbations.
The role of environmental control in asthma prevention and treatment requires ongoing evaluation.

Purpose of the Study:

To review and interpret recent literature on environmental control in asthma.
To assess the efficacy of environmental interventions in asthma prevention.
To evaluate the role of environmental control in asthma treatment.

Main Methods:

Systematic review of recent scientific literature.
Analysis of clinical trials on environmental control interventions.
Evaluation of practice parameters for environmental control.

Main Results:

Environmental control is established for asthma management but not primary prevention.
Multifaceted interventions targeting multiple asthma triggers show efficacy.
Portable HEPA purifiers reduce indoor particulate matter and improve asthma outcomes.
Evidence-based recommendations exist for allergen control (pets, rodents, cockroaches).

Conclusions:

Environmental interventions do not appear to prevent atopic disease.
Multifaceted environmental interventions benefit asthma management, particularly in children.