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Human parechovirus-3 infection in children, South Korea

Tae-Hee Han1, Ju-Young Chung, Su Jeong You

  • 1Department of Laboratory Medicine, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|June 27, 2013
PubMed
Abstract

Insights

Human parechovirus type 3 (HPeV-3) was detected in Korean children with sepsis-like illness and meningitis. This first report highlights the need for routine HPeV-3 screening in infants presenting with these symptoms.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Human parechoviruses (HPeVs) are recognized pathogens causing severe illness in children.
  • Data on HPeV and klassevirus infections in Korea, particularly meningitis, is limited.
  • Klassevirus is an emerging cause of gastroenteritis with an unclear role in meningitis.

Purpose of the Study:

  • To investigate the epidemiology of HPeVs and klassevirus in pediatric sepsis-like illness and meningitis.
  • To detect and type these viruses in cerebrospinal fluid (CSF) samples from Korean children.

Main Methods:

  • Retrospective analysis of 183 CSF samples from patients aged 1 day to 15 years.
  • RT-PCR assay used for the detection of HPeV, Enterovirus (EV), and klassevirus.
  • Sequencing of viral gene regions (VP3/VP1, 3D for HPeV; VP1 for EV) for precise typing.

Main Results:

  • Human parechovirus type 3 (HPeV-3) was identified in 6.5% (12/183) of CSF samples.
  • Enteroviruses (EVs) were detected in 21.3% (39/183) of samples; no co-infections with HPeV-3 were observed.
  • Klassevirus was not detected; HPeV-3 infections predominantly affected infants under 3 months and occurred in summer.

Conclusions:

  • This study provides the first evidence of HPeV-3 detection in CSF samples in Korea.
  • The findings underscore the importance of HPeV-3 as a cause of meningitis and sepsis-like illness in young infants.
  • Routine screening for HPeV-3 is recommended for infants presenting with these clinical symptoms in Korea.
Keywords:
ChildrenEnterovirusHuman parechovirusKlasse virusMeningitis sepsis

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