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Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: May 10, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Pulmonary function test quality in the elderly: a comparison with younger adults.

Jeffrey M Haynes1

  • 1Pulmonary Function Laboratory, St Joseph Hospital, Nashua, New Hampshire.

Respiratory Care
|June 27, 2013
PubMed
Summary

Elderly patients achieve high-quality spirometry and diffusion capacity (DLCO) test results comparable to younger adults. This indicates pulmonary function testing is reliable for older individuals.

Keywords:
diffusing capacitypulmonary function testsspirometrytest quality

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Area of Science:

  • Pulmonary Medicine
  • Geriatric Medicine
  • Diagnostic Testing

Background:

  • Pulmonary function tests (PFTs) are underutilized in elderly patients, potentially leading to misdiagnosis and suboptimal treatment.
  • Quality expectations for PFTs in older adults may be lower, impacting clinical decision-making.

Purpose of the Study:

  • To assess if elderly patients (≥80 years) can achieve spirometry and diffusion capacity (DLCO) quality scores comparable to younger adults (40-50 years).

Main Methods:

  • Retrospective review of PFT data over 22 months.
  • Comparison of spirometry and DLCO quality scores between an elderly group (≥80 years) and a younger control group (40-50 years).

Main Results:

  • Spirometry acceptability and reproducibility criteria were met by 92.6% of the elderly group and 91.5% of the control group (P = .84).
  • DLCO acceptability and reproducibility criteria were met by 84.9% of the elderly group and 88.5% of the control group (P = .45).

Conclusions:

  • Elderly patients referred to a hospital PFT lab achieve comparable spirometry and DLCO quality scores to younger adults.
  • These findings support the reliable use of PFTs in the geriatric population for accurate diagnosis and treatment.