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Psychometrics of chronic liver disease questionnaire in Chinese chronic hepatitis B patients

Kai-Na Zhou1, Min Zhang, Qian Wu

  • 1Department of Epidemiology and Biostatistics, Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.

World Journal of Gastroenterology
|June 27, 2013
PubMed

Insights

The Chinese (mainland) chronic liver disease questionnaire (CLDQ) demonstrates good reliability, validity, and sensitivity for assessing patients with chronic hepatitis B (CHB). This tool is suitable for use in Chinese populations with CHB.

Area of Science:

  • Medical Assessment
  • Hepatology
  • Psychometrics

Background:

  • Chronic hepatitis B (CHB) is a significant global health concern, particularly in mainland China.
  • Assessing the quality of life and disease burden in CHB patients requires validated instruments.
  • The Chinese (mainland) chronic liver disease questionnaire (CLDQ) is a potential tool for evaluating CHB patients.

Purpose of the Study:

  • To evaluate the psychometric properties of the Chinese (mainland) chronic liver disease questionnaire (CLDQ).
  • To assess the reliability, validity, and sensitivity of the CLDQ in Chinese patients with chronic hepatitis B (CHB).

Main Methods:

  • A cross-sectional study involving 460 Chinese patients with CHB (including those with and without cirrhosis).
  • Psychometric evaluation included internal consistency (Cronbach's α), convergent/discriminant validity (item-scale correlation), factorial validity (principal component analysis), and sensitivity (Cohen's effect size, t-tests).
  • Comparisons were made between CHB and CHB-related cirrhosis groups, and between normal and abnormal alanine aminotransferase (ALT) levels.

Main Results:

  • The CLDQ exhibited good internal consistency reliability (Cronbach's α = 0.83).
  • Satisfactory convergent and discriminant validity were confirmed by item-scale correlations.
  • The questionnaire demonstrated sensitivity in differentiating between disease severity (cirrhosis) and biochemical markers (ALT levels).

Conclusions:

  • The Chinese (mainland) chronic liver disease questionnaire (CLDQ) possesses acceptable reliability, validity, and sensitivity.
  • The CLDQ is a suitable instrument for assessing Chinese patients with chronic hepatitis B (CHB).
Abstract

Keywords:
Chronic hepatitis BChronic liver disease questionnaireReliabilitySensitivityValidity

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