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Updated: May 10, 2026

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells
Published on: March 8, 2024
Targeting two co-operating cytokines efficiently shapes immune responses
Andreas A Hombach1, Hinrich Abken
1Department I of Internal Medicine; Center for Molecular Medicine Cologne (CMMC); University Hospital Cologne; University of Cologne; Cologne, Germany.
Abstract:
For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cancer than the use of each cytokine alone.
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