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Updated: May 10, 2026

Expansion and Enrichment of Gamma-Delta (γδ) T Cells from Apheresed Human Product
Published on: September 22, 2021
Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
Dieter Kabelitz1, Shirin Kalyan, Hans-Heinrich Oberg
1Institute of Immunology; University of Kiel; Kiel, Germany.
Abstract:
The Vδ2 and non-Vδ2 (mainly Vδ1) subsets of human γδ T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of Vδ2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-Vδ2 γδ T cells preferentially recognize stress-associated surface antigens. Here, we discuss the pros and cons of Vδ2 versus non-Vδ2 γδ T cells as tools for future immunotherapeutic interventions against cancer.
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