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Updated: May 10, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
Regulation of DC development and DC-mediated T-cell immunity via CISH
Mohammad Alam Miah1, Yong-Soo Bae
1Department of Biological Sciences; Sungkyunkwan University; Suwon, Gyeonggi-do, South Korea ; Department of Physiology; Bangladesh Agricultural University; Mymensingh, Bangladesh.
Abstract:
Cytokine inducible SH2-containing protein (CISH) plays a crucial role in type 1 dendritic cell (DC) development as well as in the DC-mediated activation of cytotoxic T lymphocytes (CTLs). CISH expression at late DC developmental stages shuts down the proliferation of DC progenitors by negatively regulating signal transducer and activator of transcription 5 (STAT5) and facilitates the differentiation of DCs into potent stimulators of CTLs.
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