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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
Stephanie Chang1, Xue Lin, Ryuji Higashikubo
1Department of Surgery, Division of Cardiothoracic Surgery, Alvin Siteman Cancer Center and Department of Pathology and Immunology Washington University School of Medicine.
Abstract:
Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.
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