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Determination of warfarin in drinking water by high-performance liquid chromatography after solid-phase extraction
J Dalbacke1, I Dahlquist, C Persson
1Analytical and Quality Development Department, Gacell Laboratories AB, Malmö, Sweden.
Journal of Chromatography
|May 16, 1990
Abstract:
A method for the determination of 0.1 micrograms/l of warfarin in drinking water involving concentration by solid-phase extraction is described. A 1000-ml volume of drinking water is aspirated through a solid-phase extraction column and warfarin is eluted to 1.0 ml. The eluate is analysed by reversed-phase high-performance liquid chromatography with UV detection. The detection limit is 0.02 micrograms/l. Recoveries of greater than 90% were obtained when tap water was spiked with warfarin.